Mean Kinetic Temperature Calculator

Compute the mean kinetic temperature (MKT) that regulators use to summarise the cumulative thermal stress on pharmaceuticals, biologics, and diagnostic reagents. Enter the activation energy specified in your stability protocol along with up to ten logged storage temperatures in °C to obtain the equivalent constant temperature that would produce the same degradation rate.

Use 83.144 kJ/mol unless your stability protocol specifies a different activation energy.
Enter the first logged storage temperature in degrees Celsius.
Enter the second logged storage temperature in degrees Celsius.
Enter the third logged storage temperature in degrees Celsius.
Optional fourth measurement if you have more than three data points.
Optional fifth measurement if you have more than four data points.
Optional sixth measurement if you have more than five data points.
Optional seventh measurement if you have more than six data points.
Optional eighth measurement for long-term monitoring datasets.
Optional ninth measurement for long-term monitoring datasets.
Optional tenth measurement for long-term monitoring datasets.

Examples

  • Activation energy 83.144 kJ/mol with readings 4 °C, 6 °C, 8 °C, 14 °C, 18 °C ⇒ 9.72 °C MKT.
  • Activation energy 90 kJ/mol with readings -10 °C, 2 °C, 5 °C, 12 °C, 16 °C, 22 °C ⇒ 11.58 °C MKT.

FAQ

Why is the activation energy defaulted to 83.144 kJ/mol?

ICH stability guidelines cite 83.144 kJ/mol as a representative activation energy for many drug products. Use substance-specific data from your stability protocol whenever it is available.

How many temperature readings should I include?

Include every distinct mean kinetic temperature interval from your data logger. The calculator accepts up to ten values; when you have more, average readings by day or hour before entering them.

Does the calculator support Fahrenheit readings?

Convert °F to °C using the Temperature Conversion calculator before input. Mean kinetic temperature calculations must be performed in Kelvin to remain thermodynamically consistent.

Additional Information

  • Mean kinetic temperature emphasises high excursions because the Arrhenius weighting magnifies warmer intervals relative to cooler ones.
  • Use the calculator alongside the Temperature Conversion and Dew Point calculators when auditing cold-chain performance reports.
  • MKT is reported in °C for readability, but the computation internally uses Kelvin to maintain SI coherence.

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