Biotech Batch Yield Loss Cost Calculator
Quantify how yield loss erodes biotech batch revenue and test the ROI of remediation projects. Enter the revenue from a fully successful batch and the expected loss percentage to size annual leakage, forecast recovered dollars after improvements, and gauge simple payback on mitigation spend.
For GMP decision-making, pair these estimates with process validation data and finance review.
Examples
- $1,200,000 revenue per batch, 7% loss, 12 batches/year, 50% reduction, $350,000 mitigation ⇒ Yield loss per batch: $84,000.00 • Annual revenue leakage: $1,008,000.00 • Recovered annually if loss cut by 50.00%: $504,000.00 • Simple payback: 0.69 years
- $900,000 revenue per batch, 9% loss, 10 batches/year, 40% reduction, $1,500,000 mitigation ⇒ Yield loss per batch: $81,000.00 • Annual revenue leakage: $810,000.00 • Recovered annually if loss cut by 40.00%: $324,000.00 • Simple payback: 4.63 years
FAQ
Can I convert the recovered revenue into EBITDA impact?
Yes. Multiply the recovered revenue by your EBITDA margin to estimate the contribution to earnings.
How do I handle variable batch sizes?
Use a weighted-average revenue per batch that reflects the mix of production campaigns throughout the year.
Does the calculator account for scrap resale value?
No. Subtract any salvage or insurance recovery from the revenue per batch before entering it.
What if mitigation requires ongoing OPEX?
Add the annual operating cost to the mitigation investment or subtract it from the recovered revenue to refine the payback.
Additional Information
- Loss percentage should aggregate failure modes such as contamination, equipment downtime, and quality rejections for the product family.
- Recovered revenue assumes the mitigation project permanently reduces the loss percentage by the selected amount.
- Simple payback excludes depreciation, tax effects, and ongoing operating costs tied to process analytical technology.